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p53 keeps bystanders at the gates. | LitMetric
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p53 keeps bystanders at the gates.

Michael A Fray Stephen C Bunnell

Immunity

Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA; Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address:

Published: May 2014

The inappropriate expansion of self-reactive "bystander" T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800040PMC
http://dx.doi.org/10.1016/j.immuni.2014.05.001DOI Listing

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