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Insight into the molecular initiating event of mutagenic N-nitrosamines: a computational study on DNA alkylation by their diazonium ions.
Environ Toxicol Chem
January 2025
School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou, China.
N-Nitrosamines are a class of compounds that includes the potent mutagenicity and carcinogenicity of many of its members and is distributed widely throughout the human environment. DNA alkylation by their diazonium ions formed metabolically acts as a molecular initiating event (MIE) that links molecular chemistry to mutagenicity. However, the regiochemistry for diazonium ions reacting with DNA bases is still under debate.
View Article and Find Full Text PDFHealth system financing fragmentation and maternal mortality transition in Mexico, 2000-2022.
Int J Equity Health
January 2025
Center for Health Systems Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Objective: To analyze the temporal and territorial relationship between health system financing fragmentation and maternal mortality in the last two decades in Mexico.
Methods: We conducted an ecological-longitudinal study of the maternal mortality ratio (MMR) in the 32 states of Mexico during the period 2000-2022. Annual MMRs were estimated at the national and state levels according to health insurance.
Quantifying the shift of public export finance from fossil fuels to renewable energy.
Nat Commun
January 2025
Climate Finance and Policy Group, ETH Zurich, Zurich, Switzerland.
By providing guarantees and direct lending, public export credit agencies (ECAs) de-risk and thus enable energy projects worldwide. Despite their importance for global greenhouse gas emission pathways, a systematic assessment of ECAs' role and financing patterns in the low-carbon energy transition is still needed. Using commercial transaction data, here we analyze 921 energy deals backed by ECAs from 31 OECD and non-OECD countries (excluding Canada) between 2013 and 2023.
View Article and Find Full Text PDFmTOR/p70S6K signaling pathway promotes fibrillin-1 expression in AKI-to-CKD transition post CA/CPR.
Cell Signal
January 2025
School of Basic Medicine, Jiamusi University, Jiamusi 154007, PR China. Electronic address:
The possible involvement of mTOR/p70S6K signaling in mediating Fibrillin-1 expression during the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) after cardiac arrest and cardiopulmonary resuscitation (CA/CPR). A CA/CPR AKI model was established using male C57BL/6 mice aged 8-12 weeks. The expression of Fibrillin-1 and activation of the mTOR/p70S6K signaling pathway in kidney tissues were assessed at different time points.
View Article and Find Full Text PDFBimetallic FeCo phosphide-enabled electrochemical sensor for rapid tanshinol quantification in Salvia miltiorrhiza herb at near-neutral condition.
Talanta
January 2025
School of Pharmaceutical Sciences, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address:
Tanshinol, an active ingredient extracted from the Salvia miltiorrhiza herb, is widely used in Chinese medicine or health supplements. Accurately and rapidly quantifying of tanshinol under near-neutral or neutral conditions is of great significance but still a significant challenge. Herein, a novel electrochemical sensor based on bimetallic FeCo phosphides (FeCoP) was developed for rapid and sensitive detection of tanshinol in near-neutral environments.
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