Unlabelled: Postinfectious bronchiolitis obliterans (PIBO) is an infrequent chronic lung that causes irreversible obstruction and, or, obliteration of the smaller airways. This review particularly focuses on more than 30 studies from South America.
Conclusion: The initial PIBO event occurs in the early years of life and is strongly associated with adenovirus infection and the need for mechanical ventilator support. Treatment requires a multidisciplinary strategy. Multicentre studies are needed to determine progression, optimal management and long-term follow-up.
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http://dx.doi.org/10.1111/apa.12689 | DOI Listing |
Ann Med
December 2025
Hunan Provincial Key Laboratory of Pediatric Respirology, Pediatric Medical Center, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, P. R. China.
Background: Adenovirus (ADV) pneumonia in children is a significant contributor to the occurrence of post-infectious bronchiolitis obliterans (BO). Heparin sodium has known anti-inflammatory, immunomodulatory, and tissue repair properties. However, its role in treating BO after ADV infection remains unclear.
View Article and Find Full Text PDFBMC Pediatr
November 2024
Department of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, NO.56, Nanlishi Road, Beijing, 100045, P. R. China.
Pediatr Pulmonol
November 2024
The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Background: Risk factors for progression of adenovirus (AdV)-associated bronchiolitis (AdV-B) to post-infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort.
Methods: A multicenter hospital-based analysis included children admitted with AdV-B in Jerusalem during 2016-2022.
Pediatr Pulmonol
October 2024
Respiratory Center of the Hospital de Niños Ricardo Gutierrez, Ciudad de Buenos Aires, Argentina.
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