Background: Cutaneous Rosai-Dorfman disease is a rare disorder belonging to the spectrum of non-Langerhans cell histiocytoses. It is characterized by dermal and subcutaneous infiltrates of histiocytes as well as accompanying lymphocytes, plasma cells and granulocytes. Because it is so rare, standard therapies have not been established.
Case Report: A 27-year-old man showed an excellent response to intralesional corticosteroids after unsuccessful prior treatment with methotrexate, systemic steroids and surgery as well as laser therapy.
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| http://dx.doi.org/10.1007/s00105-014-2797-0 | DOI Listing |
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Response to the commentary on "Cutaneous rosai-dorfman disease: a systematic review and reappraisal of its treatment and prognosis".
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Article Synopsis
- Rosai-Dorfman disease (RDD) is a rare, benign disorder characterized by an overgrowth of histiocytes, typically affecting lymph nodes but can also present with skin lesions.
- Diagnosis often requires histopathological and immunohistochemical analysis, as RDD can resemble cancer during clinical examination and imaging.
- The case of a 59-year-old woman with a rapidly growing nodular plaque on her cheek highlights the variability of RDD and the need for careful evaluation to ensure accurate diagnosis and treatment plans.
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