Most of the available multivariate statistical models dictate on fitting different parameters for the covariate effects on each multiple responses. This might be unnecessary and inefficient for some cases. In this article, we propose a modelling framework for multivariate marginal models to analyze multivariate longitudinal data which provides flexible model building strategies. We show that the model handles several response families such as binomial, count and continuous. We illustrate the model on the Kenya Morbidity data set. A simulation study is conducted to examine the parameter estimates. An R package mmm2 is proposed to fit the model.
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http://dx.doi.org/10.1016/j.cmpb.2014.04.005 | DOI Listing |
Am J Cancer Res
December 2024
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
No established method currently exists for evaluating tumor-infiltrating lymphocytes (TILs) in gastric cancer (GC), and their clinical significance based on infiltration site in GC remains unclear. In this study, we developed a method to evaluate TILs according to their infiltration site as a prognostic marker for GC. We retrospectively analyzed 103 patients with advanced GC who underwent curative resection.
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of Radiotherapy Oncology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453100, People's Republic of China.
Background: The Naples prognostic score (NPS) and its relation to the prognosis of oral squamous cell carcinoma (OSCC) have been inconclusive. This study aimed to investigate the correlation between NPS and the prognosis of postoperative OSCC patients. Additionally, the study sought to develop a new nomogram for predicting disease-free survival (DFS) and overall survival (OS).
View Article and Find Full Text PDFJ Surg Oncol
January 2025
Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) of the body/tail is notably different than PDAC in the head of the pancreas. Surgery plus chemotherapy is known to improve outcomes for all PDAC. The sequence of this therapy is well studied in head cancers yet has never been evaluated systematically in relation to distal pancreatectomy (DP).
View Article and Find Full Text PDFInt J Urol
January 2025
Department of Urology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Background: Studies comparing oncological outcomes between robot-assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP) are often limited by bias because of their multi-institutional and multiple surgeon design. Studies from a single institution and single surgeon are uncommon.
Objective: To compare oncological outcomes between RARP and ORP at a single institution by a single surgeon.
Environ Pollut
January 2025
Federal Institute of Maranhão, Campus Barreirinhas, Rodovia MA-225, KM 04, CEP:65590-000, Barreirinhas, Maranhão, Brazil.
Dredging in estuarine systems significantly impacts phytoplankton communities, with suspended particulate matter (SPM) and dissolved aluminum (Al) serving as indicators of disturbance intensity. This study assessed the effects of dredging in the São Marcos Estuarine Complex (SMEC), Brazil, over three distinct events (2015, 2017, 2020), involving varying sediment volumes and climatic influences. Prolonged dredging operations and increased sediment volumes led to a pronounced 43.
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