Executive functions (EF) in autism spectrum disorders (ASD) have been often investigated, although results seem to be rather inconsistent. The first aim of this study was to detect which EF components are common to the ASD continuum (from high- to low-functioning ASD) and identify a possible EF profile for ASD people. Planning, mental flexibility, inhibition of response, generativity, and ecologic EF were investigated. This study was extended not only to high-functioning ASD, but also to ASD with intellectual disability (ID). The second aim was to find EF aspects correlating with adaptive skills in ASD. A total of 61 children participated in the study (27 ASD with and without ID and 34 controls). Results highlight an executive profile characterised by impaired flexibility and deficient planning; these deficits are associated with decreased adaptive ability, particularly socialization, and a deficient shifting in ecologic conditions. These features are present in all ASD subgroups with and without ID; for this reason, they might be assumed as being specific features in ASD.
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http://dx.doi.org/10.1155/2014/941809 | DOI Listing |
ISA Trans
December 2024
ATS Lab, Air Force Engineering University, 710038 Xi'an, China.
The prediction of the remaining useful life (RUL) holds significant importance within the field of prognostics and health management (PHM), which may provide lifetime information about the system. The foundation for effectively estimating RUL is constructing an applicable degradation model for the system. However, the majority of existing degradation models only consider the issue of age dependence and disregard state dependence.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
December 2024
Dept. Science, Roma Tre University, Rome, Italy; Neuroendocrinology, Metabolism and Neuropharmacology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy. Electronic address:
β-Caryophyllene (BCP) is a naturally occurring sesquiterpene found in numerous plant species, including Cannabis sativa. BCP has shown a high safety profile and a wide range of biological functions, including beneficial effects in neurodegenerative and inflammatory diseases. Here, we used behavioral, pharmacological, and in-silico docking analyses to investigate the effects and mechanism of action of BCP in Fragile X Syndrome (FXS), the most common inherited cause of Autism Spectrum Disorder (ASD) and intellectual disability.
View Article and Find Full Text PDFInterdiscip Cardiovasc Thorac Surg
December 2024
Division Head, cardiovascular Surgery, Hospital for Sick Children, Toronto, Director of Adult Congenital Heart Surgery, Toronto General Hospital ACHD Unit, and Professor, University of Toronto, Canada.
A_small_ASD_with right-to-left shunt is useful for off-loading a dysfunctional right ventricle postoperatively. However, an ASD with left-to-right shunt may not be as useful for a dysfunctional left ventricle. Experimental data is limited at present.
View Article and Find Full Text PDFEur Child Adolesc Psychiatry
December 2024
Department of Plastic Surgery, Evelina Hospital, St Thomas' Hospital, London, UK.
Individuals with orofacial clefts (OFCs) may be at an increased risk of developing autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). This systematic review provides a summary of the most recent data regarding the prevalence of ASD and ADHD in the OFC population and compares this to the general paediatric population. Multiple databases were searched including PubMed/Medline and Embase in July 2024, following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines and was registered in PROSPERO (CRD42024565219).
View Article and Find Full Text PDFJ Clin Psychiatry
December 2024
Department of Psychiatry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India; Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Up to 10% of women may use cannabis during pregnancy; this is of concern because constituents of cannabis cross the placental barrier and potentially influence neurodevelopment by acting on cannabinoid receptors in the developing fetal brain. In this context, a recent meta analysis of 13 observational studies found that gestational exposure to cannabis was associated with a small increase in the risk of autism spectrum disorder (ASD; relative risk [RR], 1.30) and with an even smaller increase in the risk of attention deficit/hyperactivity disorder (ADHD; RR, 1.
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