AI Article Synopsis
- The study aimed to compare health-related quality of life (HRQoL) scores using two different instruments (SF-6D and 15D) in patients with ST-elevation myocardial infarction (STEMI) to assess their impact on quality adjusted life years (QALYs).
- Conducted as a sub-study of the Norwegian District Treatment of STEMI, it collected HRQoL data from 248 patients across multiple visits after receiving either early angioplasty or standard treatment.
- Results showed that mean utility scores were higher for the 15D instrument compared to the SF-6D; however, the choice of instrument did not significantly affect the overall gain in QALYs between the two treatment approaches
Article Abstract
Objectives: The aim of this study was to compare health-related quality of life (HRQoL) scores obtained from the instrument Short Form (SF)-36 through the so-called SF-6D utilities, and those obtained from 15D, in patients with ST-elevation myocardial infarction (STEMI), and to evaluate the consequences in estimation of quality adjusted life years (QALYs).
Design: This was a sub-study of the Norwegian District Treatment of STEMI, in which patients with STEMI treated with tenecteplase, were randomized to early angioplasty or standard management (n = 266). HRQoL data were collected at all visits (0, 1, 3, 7 and 12 months). All patients with complete data were included (n = 248).
Results: The score range was 0.33-1.0 for SF-6D and 0.49-1.0 for 15D. Mean utility scores from 15D were higher and had different distribution compared to scores from SF-6D. Mean QALY for the whole group was higher using 15D than SF-6D (0.89 vs. 0.77). The incremental number of QALYs with early angioplasty compared to standard treatment was 0.005 (95% CI: - 0.018 to 0.028) using SF-6D, and 0.004 (95% CI: - 0.010 to 0.018) using the 15D instrument.
Conclusions: Choice of instrument may influence HRQoL scores, but not necessarily the gain in QALYs.
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| http://dx.doi.org/10.3109/14017431.2014.923581 | DOI Listing |
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