The present study was conducted to evaluate the hepatoprotective activity of different extracts of Tinospora cordifolia against carbon tetrachloride (CCl4) induced liver damage in rats. The pet ether, ethanol and aqueous extracts of various parts of the plant such as leaf, stem and root were tested at the dose of 200mg/kg body weight orally using Wistar albino rats and Silymarin was given as reference standard. Ethanolic extract of all the parts showed significant hepatoprotective effect by reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected model which is followed by aqueous and pet ether extracts. The chemical constituents reported from the plant belong to different classes such as alkaloids, flavanoids, glycosides, steroids, terpenoids, phenolics and saponins. The overall experimental results suggests that the biologically active phytoconstituents such as flavonoids, alkaloids present in the ethanolic extract of plant Tinospora cordifolia, may be responsible for the significant hepatoprotective activity. Therefore, results justify the use of Tinospora cordifolia as a hepatoprotective agent.
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Article Synopsis
- Metabolic disorders are a major global health issue, prompting research into drugs with improved effectiveness and fewer side effects, particularly from traditional Indian medicine using Tinospora cordifolia and Tinospora sinensis.
- The study aimed to identify unique metabolite fingerprints from these plants across various geographic locations and establish potential quality markers for treatment.
- Non-targeted metabolite fingerprinting techniques revealed six key marker compounds, with specific metabolites linked to geographic variations, indicating trans piceid, crustecdysone, and gallic acid as promising candidates for addressing metabolic disorders, though further studies are needed to confirm these results.
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