Purpose: To investigate the anti-ulcerogenic properties of the chloroform extract of Flemingia strobilifera root in rats.
Methods: Anti-ulcer effect was evaluated by water immersion induced ulcer in rats. Other anti-ulcer related activities of the extract such as the effects on free radicals and antimicrobial activity were also evaluated.
Results: Chloroform extract of Flemingia strobilifera root was found to be safe up to 300 mg/kg body weight when administrated orally in female wistar rats. Water immersion stress produced characteristic lesions in the glandular portion of the rat stomach. Pretreatment with Chloroform extract of Flemingia strobilifera root reduced the characteristic lesions in a dose dependent manner (P<0.001) when compared with the control. Pretreatment with Chloroform extract of Flemingia strobilifera root at a dose of 15 and 30 mg/kg body wt. increased the gastric mucosal glutathione level, total protein content significantly (P<0.001) as compared to control group. Whereas there is significant (P<0.05, P<0.001) reduction in gastric mucosal Malonaldehyde levels when compared to control. Free radical scavenging activity of Chloroform extract of Flemingia strobilifera root was observed in the concentration range tested, the IC50 value was calculated. Antimicrobial activity of the Chloroform extract of Flemingia strobilifera root exhibited activity against both gram positive and negative bacteria at concentration of 10 mg/ml.
Conclusion: The root extract of Flemingia strobilifera possess antiulcerogenic properties could justify folklore uses of the plant in peptic ulcer diseases.
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Arch Pharm Res
May 2018
College of Pharmacy, Sookmyung Women's University, Seoul, 04310, Republic of Korea.
Phytoestrogen (PE) has received considerable attention due to the physiological significance of its estrogenicity. Flemingia strobilifera (FS) has been used as a folk medicine in Asia for the treatment of inflammation, cancer, and infection; however, the estrogenic effects and chemical components of FS have not yet been reported. We aimed to uncover the estrogenic properties and PEs derived from FS using phytochemical and pharmacological evaluation.
View Article and Find Full Text PDFPharmacognosy Res
October 2013
Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, IFTM University, Moradabad, India ; Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India.
Background: Flemingia strobilifera (FS) R.Br. (Fabaceae) is an important medicinal plant.
View Article and Find Full Text PDFWest Indian Med J
December 2010
Pharmacology Unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago, West Indies.
Objective: To assess the cytotoxic activities of crude extracts and solvent fractions of Spermacoce verticillata, Ficus pumila and Flemingia strobilifera against a MT-4 human leukaemia cancer cell line.
Methods: Crude extracts of dried leaves of S verticillata, F pumila and F strobilifera were made by exhaustive methanol extraction, fractions were obtained from sequential extraction of the crude extract using solvents of increasing polarity. Dose responses corresponding to cell survival following 72-hour exposure to the extracts were determined using a leukaemia cancer cell line (MT-4).
J Basic Clin Pharm
December 2010
Department of Biotechnology, Government Science College, Nrupatunga road, Bangalore, India.
Purpose: To investigate the anti-ulcerogenic properties of the chloroform extract of Flemingia strobilifera root in rats.
Methods: Anti-ulcer effect was evaluated by water immersion induced ulcer in rats. Other anti-ulcer related activities of the extract such as the effects on free radicals and antimicrobial activity were also evaluated.
Acta Pol Pharm
August 2009
Central Indian Pharmacopoeia Laboratory, Ministry of Health and Family Welfare, Sector-23, Raj Nagar, Ghaziabad, U.P.-201002, India.
A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone along with the known phytoconstituents: 5,7,2',4'-tetrahydroxyisoflavone (2), 5,7,4'-trihydroxyisoflavone (3) and beta-sitosterol (4).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!