AI Article Synopsis
- The study uses a specific algorithm to determine if a certain genomic position shows different levels of methylation among various samples.
- It highlights the benefits of this algorithm compared to two common methods: Fisher's test and Z score, which may be less accurate.
- The mathematical approach discussed can also be adapted for use in calling genetic variants.
Article Abstract
We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019606 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097349 | PLOS |
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