Soft tissue sarcomas are rare tumours requiring a multidisciplinary approach of the diagnostic process, the treatment and the follow up. Radical surgery remains the basis of the oncological treatment. Adjuvant radiotherapy is often added to surgery because of a high risk of local recurrence for specified patient groups. Nowadays, the adjuvant approach is often replaced by a neo-adjuvant approach as this pre-operative radiotherapy offers several advantages. We will also discuss the adaptation of the surgery to the radiotherapy and vice versa, and we present the clinical pathway for most of soft tissue sarcoma patients. We conclude with a series of technical innovations.
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