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Mechanisms underlying HIV-1 Vpu-mediated viral egress. | LitMetric

Mechanisms underlying HIV-1 Vpu-mediated viral egress.

Front Microbiol

INSERM U1016, Institut Cochin Paris, France ; CNRS UMR8104 Paris, France ; Université Paris Descartes Paris, France.

Published: June 2014

AI Article Synopsis

Article Abstract

Viruses such as lentiviruses that are responsible for long lasting infections have to evade several levels of cellular immune mechanisms to persist and efficiently disseminate in the host. Over the past decades, much evidence has emerged regarding the major role of accessory proteins of primate lentiviruses, human immunodeficiency virus and simian immunodeficiency virus, in viral evasion from the host immune defense. This short review will provide an overview of the mechanism whereby the accessory protein Vpu contributes to this escape. Vpu is a multifunctional protein that was shown to contribute to viral egress by down-regulating several mediators of the immune system such as CD4, CD1d, NTB-A and the restriction factor BST2. The mechanisms underlying its activity are not fully characterized but rely on its ability to interfere with the host machinery regulating protein turnover and vesicular trafficking. This review will focus on our current understanding of the mechanisms whereby Vpu down-regulates CD4 and BST2 expression levels to favor viral egress.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013480PMC
http://dx.doi.org/10.3389/fmicb.2014.00177DOI Listing

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