AI Article Synopsis
- Motor neuron diseases have no cure, but research using induced pluripotent stem cells is revealing important disease-related features.
- The discussion includes strategies for modeling various facets of motor neuron disease and identifying the specific neurons affected.
- Recent advancements focus on common types of motor neuron diseases, such as amyotrophic lateral sclerosis, hereditary spastic paraplegia, and spinal muscular atrophy.
Article Abstract
While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then describe recent progress to investigate common forms of motor neuron disease: amyotrophic lateral sclerosis, hereditary spastic paraplegia and spinal muscular atrophy.
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| http://dx.doi.org/10.1093/hmg/ddu205 | DOI Listing |
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