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Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes.
J Biomed Opt
February 2025
National Institute of Standards and Technology, Applied Physics Division, Boulder, Colorado, United States.
Significance: Developments of anti-gametocyte drugs have been delayed due to insufficient understanding of gametocyte biology. We report a systematic workflow of data processing algorithms to quantify changes in the absorption spectrum and cell morphology of single malaria-infected erythrocytes. These changes may serve as biomarkers instrumental for the future development of antimalarial strategies, especially for anti-gametocyte drug design and testing.
View Article and Find Full Text PDFPlasmodium falciparum CyRPA glycan binding does not explain adaptation to humans.
Genome Biol Evol
January 2025
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
The human malaria parasite Plasmodium falciparum evolved from a parasite that infects gorillas, termed Plasmodium praefalciparum. The sialic acids on glycans on the surface of erythrocytes differ between humans and other apes. It has recently been shown that the P.
View Article and Find Full Text PDFPrevalence and Risk Factors of Malaria in Iwaka District, Mimika, Papua.
Acta Med Indones
October 2024
Department of Parasitology, Faculty of Medicine Universitas Islam Indonesia, Yogyakarta, Indonesia.
Background: Papua is a high-endemic region for malaria in Indonesia. Malaria transmission is heavily influenced by environmental factors, particularly those related to vector breeding habitats and the homes of infected individuals. Communities in high-endemic areas also exhibit risk behaviors that can increase the likelihood of malaria transmission.
View Article and Find Full Text PDFLow-Cost and Portable Biosensor Based on Monitoring Impedance Changes in Aptamer-Functionalized Nanoporous Anodized Aluminum Oxide Membrane.
Micromachines (Basel)
December 2024
Ames National Laboratory, Mechanical Engineering Department, Iowa State University, Ames, IA 50014, USA.
We report a low-cost, portable biosensor composed of an aptamer-functionalized nanoporous anodic aluminum oxide (NAAO) membrane and a commercial microcontroller chip-based impedance reader suitable for electrochemical impedance spectroscopy (EIS)-based sensing. The biosensor consists of two chambers separated by an aptamer-functionalized NAAO membrane, and the impedance reader is utilized to monitor transmembrane impedance changes. The biosensor is utilized to detect amodiaquine molecules using an amodiaquine-binding aptamer (OR7)-functionalized membrane.
View Article and Find Full Text PDFPrevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania.
Parasit Vectors
January 2025
National Institute for Medical Research, Dar es Salaam, Tanzania.
Background: Despite implementation of effective interventions in the past two decades, malaria is still a major public health problem in Tanzania. This study assessed the prevalence and drivers of malaria infections among symptomatic and asymptomatic members of selected communities from five regions with varying endemicity in mainland Tanzania.
Methods: A cross-sectional community survey was conducted in five districts, including one district/region in Kagera, Kigoma, Njombe, Ruvuma and Tanga from July to August 2023.
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