AI Article Synopsis
- Liver pathology is a common issue following Fontan palliation, with previous studies mainly focusing on symptomatic patients.
- The study examined the liver condition of 21 asymptomatic patients using transvenous hepatic biopsies during elective cardiac catheterization.
- Results indicated that almost all patients had sinusoidal or portal fibrosis, and there was a significant correlation between fibrosis severity and the time elapsed since Fontan surgery, but no link was found between fibrosis and other clinical measurements like pressure or lab tests.
Article Abstract
Liver pathology complicates Fontan palliation. Previous reports established that both hepatic sinusoidal and portal fibrosis occur in patients after Fontan procedures. Past studies predominantly included symptomatic patient cohorts. Thus, the authors of this study aimed to characterize hepatic pathology via transvenous hepatic biopsies in 21 asymptomatic patients at the time of elective cardiac catheterization. Seven of these patients (33 %) were accompanied by an interventional procedure. Hepatic biopsies showed evidence of either sinusoidal or portal fibrosis or both in all but one patient. The findings showed a statistically significant (p = 0.005) moderately strong positive correlation between fibrosis scores and time since Fontan surgery. Additionally, no significant correlation was found between fibrosis scores and inferior vena cava pressure, pulmonary vascular resistance, platelet counts, or serum laboratory testing of hepatic function.
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| http://dx.doi.org/10.1007/s00246-014-0928-0 | DOI Listing |
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