AI Article Synopsis
- Novel purpurinimides were synthesized to explore their use as photosensitizers with long wavelength absorption, focusing on reactions involving methyl pheophorbide a.
- These compounds exhibited a significant bathochromic shift, enhancing their absorption in the red region of the spectrum (695-704 nm).
- The synthesized purpurinimides showed promising antitumor activities and greater photodynamic efficiency against A549 cell lines compared to purpurin-18 methyl ester, indicating their potential as effective photosensitizers.
Article Abstract
A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057721 | PMC |
| http://dx.doi.org/10.3390/ijms15058091 | DOI Listing |
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- These compounds exhibited a significant bathochromic shift, enhancing their absorption in the red region of the spectrum (695-704 nm).
- The synthesized purpurinimides showed promising antitumor activities and greater photodynamic efficiency against A549 cell lines compared to purpurin-18 methyl ester, indicating their potential as effective photosensitizers.
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