AI Article Synopsis
- Epigenetic regulation significantly affects gene expression in various cancers, particularly in medullary thyroid carcinomas (MTC).
- The study analyzed the expression of epigenetic regulators in 54 MTC samples, with a focus on their correlation with clinical outcomes and patient mutations.
- Increased expression of the genes EZH2 and SMYD3 was linked to more aggressive forms of MTC, suggesting they could serve as potential prognostic biomarkers for treatment decisions.
Article Abstract
Epigenetic control of gene expression plays a major influence in the development and progression of many cancer types. Aim of the present study was to investigate the expression of epigenetic regulators in a large cohort of medullary thyroid carcinomas (MTC), correlating the data with the clinical outcome and mutational status of the patients. Taqman Low Density Arrays (TLDAs) were used to analyze expression levels of several genes involved in the epigenetic control of transcription in a series of 54 MTCs. The patients cohort included 13 familial MTCs and 41 sporadic forms; 33 hosted a RET mutation and 13 a RAS somatic mutation. The expression profiling revealed in the more aggressive diseases (i.e. occurrence of metastases; persistent disease; disease-related death) a significant increase of EZH2 and SMYD3 gene expression. The increased levels of EZH2 and SMYD3 did not correlate significantly with mutational status of RET or RAS genes. Thus, the histone methyltransferases EZH2 and SMYD3 mRNA expression may represent useful prognostic biomarkers tailoring the most appropriate follow-up and timing of therapeutic approaches.
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| http://dx.doi.org/10.1016/j.mce.2014.04.016 | DOI Listing |
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