Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option.
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http://dx.doi.org/10.1016/j.jaad.2014.03.030 | DOI Listing |
Pediatr Dermatol
January 2025
Department of Health Sciences, Section of Dermatology, University of Florence, Firenze, Italy.
Pediatr Dermatol
January 2025
Department of Dermatology, Tufts Medical Center, Boston, Massachusetts, USA.
We report two pediatric patients of Chinese descent with atopic dermatitis (AD) who developed labial melanotic macules in the absence of previous topical calcineurin inhibitor (TCI) usage. Both patients presented with multiple hyperpigmented macules on the upper and lower vermilion lips with a negative genetic workup for Peutz-Jeghers. These findings suggest labial melanotic macules may be a cutaneous manifestation of chronic eczematous dermatitis in pediatric patients, particularly those of Asian descent.
View Article and Find Full Text PDFAllergy
January 2025
Department of Dermatology, Allergology and Venereology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany.
We assessed STAT activation in T cells in blood and skin of AD patients versus HC. pSTAT5 T cells were increased in AD blood, correlated with disease activity, and were induced by common γc cytokines. Skin T cells exhibited a STAT6 signature, whereas only a subset was positive for STAT5.
View Article and Find Full Text PDFExp Dermatol
February 2025
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Glucocorticoids (GCs) are synthesised de novo by peripheral tissues and the adrenal cortex of the hypothalamic-pituitary-adrenal axis. Skin expresses an enzyme called 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reduces cortisone to the active hormone cortisol which activates GC receptors. 11β-HSD1 plays a significant role in alleviating atopic inflammation through the elevation of the concentrations of active GC in the skin.
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