Objective: To investigate the transmitting phlebotomine sandfly in Minfeng County, a newly-identified endemic area of visceral leishmaniasis in the south of Talim Pendi of Xinjiang.
Methods: Sandflies were collected using routine methods in and around the Yatonggusi village of Andier Township. The sandflies were identified to get their composition. Sandfly density was calculated following an observation at a given spot and time-period, and their appearance was recorded at night-time and day-time. Sandflies were dissected to analyze the gonotrophic cycle and to find infection of promastigotes.
Results: Phlebotomus wui was identified as the transmitting vector of visceral leishmaniasis in Andier Township, which occupied 99.2% of the sandflies collected. The first and second ten-day period of June was the first peak of its seasonal distribution. Analysis of the gonotrophic cycle revealed that Ph. wui was an exophilic species and appeared nocturnally for feeding with preference to human blood. Natural infection with promastigotes was found in 2 sandflies.
Conclusion: Phlebotomus wui is the transmitting vector for visceral leishmaniasis in the newly found endemic area of south Xinjiang.
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PLoS Negl Trop Dis
December 2024
Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia.
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae.
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December 2024
Laboratory of Cell and Molecular Biology, Department of Botany, Centre of Advanced Study, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, 700019 India.
Visceral Leishmaniasis, caused by is the second most deadly parasitic disease, causing over 65,000 deaths annually. Synthetic drugs available in the market, to combat this disease, have numerous side effects. In this backdrop, we aim to find safer antileishmanial alternatives with minimal side effects from mushrooms, which harbour various secondary metabolites with promising efficacy.
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December 2024
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, 51006, Tartu, Estonia.
The analysis of the volatile compounds released by biological samples represents a promising approach for the non-invasive diagnosis of a disease. The present study, focused on a population of dogs infected with canine leishmaniasis, aimed to decipher the volatolomic profile associated with this disease in dogs, which represent the main animal reservoir for Leishmania pathogen transmission to humans. The volatiles emitted by the breath and hair of dogs were analysed employing the gas chromatography-mass spectrometry (GC-MS) technique.
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January 2025
Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University, Campus Almora, Almora, Uttarakhand India.
Unlabelled: Visceral leishmaniasis (VL), caused by , remains challenging to treat due to severe side effects and increasing drug resistance associated with current chemotherapies. Our study investigates the anti-leishmanial potential of from Uttarakhand, India, with extracts prepared from leaves and stems using ethanol and hexane. Advanced GC-MS analysis identified over 100 bioactive compounds, which were screened using molecular docking to assess their binding to LdHEL-67, a DDX3-DEAD box RNA helicase of donovani.
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December 2024
Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Basic Oncology, Institute of Health Sciences, Ege University, Izmir, Turkey; Translational Pulmonary Research Center (EGESAM), Ege University, Izmir, Turkey. Electronic address:
Leishmaniasis is a neglected infectious disease that affects millions of people worldwide. Visceral leishmaniasis (VL) caused by Leishmania infantum and cutaneous leishmaniasis (CL) caused by L. major/ L.
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