Purpose: Cusp extension technique (CET) is a reparative surgical procedure for restoring aortic valve function by suturing patches to the compromised native leaflets. Its outcomes are strongly dependent on the ability of the surgeon. We proposed and tested a novel approach on an in vitro model, aimed at standardizing and simplifying the surgical procedure.
Methods: A set of standard pre-cut bovine pericardium patches, available in different sizes, was developed. The surgeon can choose the leaflet-specific patches to be implanted according to the patient anatomy, using a geometrical model of the aortic valve whose inputs are the measured intercommissural distances. The hemodynamic performance of this approach was evaluated on porcine aortic roots in a pulsatile mock loop. Hydrodynamic and kinematic evaluation of the samples was provided.
Results: After CET, mean and maximum pressure drops were 3.1±1.3 mmHg and 25.4±5.0 mmHg respectively, and EOA was 3.8±0.8 cm.
Conclusions: Our approach to cusp extension proved to be reliable and effective in restoring valve functioning, without significantly altering the physiological kinematics. The use of pre-cut patches considerably simplified the surgery, increasing standardization and repeatability.
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http://dx.doi.org/10.5301/ijao.5000316 | DOI Listing |
J Contemp Dent Pract
January 2024
Department of General Dentistry, Advanced Education in General Dentistry Residency, AF Postgraduate Dental School, Joint Base San Antonio - Lackland, Texas; Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Phone: +1 (210) 292-0760, e-mail:
Aim: This study aimed to evaluate the marginal microleakage and maximum occlusal fracture loads and fracture modes of two novel class II preparation designs, "infinity edge" and the "2.5 mm cusp reduction" preparations as compared to a traditional class II preparation without cuspal involvement.
Materials And Methods: Thirty extracted human mandibular molars were prepared for moderate-sized class II restorations with extensions into all occlusal grooves.
Compr Rev Food Sci Food Saf
January 2024
CAISIAL Centre, University of Naples Federico II, Portici, Italy.
Seafood processing has traditionally been challenging due to the rapid spoilage rates and quality degradation of these products. With the rise of food science and technology, novel methods are being developed to overcome these challenges and improve seafood quality, shelf life, and safety. These methods range from high-pressure processing (HPP) to edible coatings, and their exploration and application in seafood processing are of great importance.
View Article and Find Full Text PDFInt J Biol Macromol
March 2024
School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea.
Regarding food security and waste reduction, preserving fruits and vegetables is a vital problem. This comprehensive study examines the innovative potential of coatings and packaging made of nanocellulose to extend the shelf life of perishable foods. The distinctive merits of nanocellulose, which is prepared from renewable sources, include exceptional gas barrier performance, moisture retention, and antibacterial activity.
View Article and Find Full Text PDFAm J Biol Anthropol
May 2024
Centre for the Exploration of the Deep Human Journey, University of the Witwatersrand, Johannesburg, South Africa.
Objectives: A modern pattern (rate and duration) of dental development occurs relatively recently during human evolution. Given the temporal overlap of Homo naledi with the first appearance of fossil Homo sapiens in Africa, this small-bodied and small-brained hominin presents an opportunity to elucidate the evolution of enamel growth in the hominin clade. Here we conduct the first histological study of two permanent mandibular canines and one permanent maxillary first molar, representing three individuals attributed to H.
View Article and Find Full Text PDFSci Rep
December 2023
Center for Life Nano Science @Sapienza, Istituto Italiano di Tecnologia, 295 Viale Regina Elena, 00161, Roma, Italy.
Since decades, the concept of vibrational density of states in glasses has been mirrored in liquids by the instantaneous-normal-mode spectrum. In glasses instantaneous configurations are believed to be situated close to minima of the potential-energy hypersurface and all eigenvalues of the associated Hessian matrix are positive. In liquids this is no longer true, and modes corresponding to both positive and negative eigenvalues exist.
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