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Adverse Impacts of PEGylated Protein Therapeutics: A Targeted Literature Review.
BioDrugs
November 2024
Würzburg University Clinic, Würzburg, Germany.
The beneficial effects of polyethylene glycol (PEG)-conjugated therapeutics, such as increased half-life, solubility, stability, and decreased immunogenicity, have been well described. There have been concerns, however, about adverse outcomes with their use, but understanding of those adverse outcomes is still relatively limited. The present study aimed to characterize adverse outcomes associated with PEGylation of protein-based therapeutics on immunogenicity, pharmacologic properties, and safety.
View Article and Find Full Text PDFDevelopment of a Temperature and pH Dual-Sensitive In-Situ Gel for Treating Allergic Conjunctivitis.
AAPS PharmSciTech
September 2024
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, P. R. China.
Article Synopsis
- The study aimed to enhance the effectiveness of olopatadine hydrochloride (OT) in treating allergic conjunctivitis (AC) by creating a new eye gel formulation using temperature-pH sensitive technology.
- The optimized dual-sensitive in situ gel (TP-gel) included specific ingredients like P407 and P188 and demonstrated a prolonged residence time on the eye's surface, lasting about four times longer than traditional eye drops.
- Testing showed that TP-gel reduced inflammation markers associated with allergic conjunctivitis in mice, indicating its potential as a promising treatment option.
Comment on "Multiple reactions during desensitization may predict decreased efficacy of PEGasparaginase chemotherapy".
Ann Allergy Asthma Immunol
October 2024
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands; Evean "Oostergouw", Center for Specialized Geriatric Care, Zaandam, The Netherlands. Electronic address:
Preparation and In Vitro Evaluation of Montelukast Sodium-Loaded 3D Printed Orodispersible Films for the Treatment of Asthma.
AAPS PharmSciTech
September 2024
University of Health Sciences, Faculty of Pharmacy, Department of Pharmaceutical Technology, Üsküdar, 34668, Istanbul, Turkey.
Article Synopsis
- - The research focuses on creating orodispersible films (ODFs) for delivering montelukast sodium, a medication for asthma and allergic rhinitis, using 3D printing and various excipients like propylene glycol and hydroxypropyl methylcellulose.
- - ODFs achieved quick disintegration (around 40 seconds) and rapid drug release (over 98% within 2 minutes), indicating their effectiveness in delivering the drug.
- - Formulations Fm1-4 and Fm2-4 showed the best drug content and durability, with no toxic effects observed, making these ODFs a promising option for treating asthma and allergic rhinitis.
Anaphylaxis after Treatment with an Endodontic Material Containing Polyethylene Glycol.
J Endod
November 2024
Dental Biomaterials Adverse Reaction Unit, NORCE Norwegian Research Centre AS, Bergen, Norway.
Polyethylene glycol (PEG) is sometimes included in temporary endodontic filling materials to modify viscosity. PEG is considered a low hazard chemical, but parenteral PEG exposure is associated with a risk of anaphylaxis. We report 2 cases of anaphylaxis after treatment with an endodontic temporary filling material containing PEG.
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