A compact implementation of a dynamic charge transfer synapse cell, capable of implementing synaptic depression, is presented. The cell is combined with a simple current mirror summing node to produce biologically plausible postsynaptic potentials (PSPs). A single charge packet is effectively transferred from the synapse to the summing node, whenever a presynaptic pulse is applied to one of its terminals. The charge packet is "weighted" by a voltage applied to the second terminal of the synapse. A voltage applied to the third terminal determines the charge recovery time in the synapse, which can be adjusted over several orders of magnitude. This voltage determines the paired pulse ratio for the synapse. The fall time of the PSP is also adjustable and is set by the gate voltage of a metal-oxide-semiconductor field-effect transistor operating in subthreshold. Results extracted from chips fabricated in a 0.35-μm complementary metal-oxide-semiconductor process, alongside theoretical and simulation results, confirm the ability of the cell to produce PSPs that are characteristic of real synapses. The concept addresses a key requirement for scalable hardware neural networks.
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http://dx.doi.org/10.1109/TNNLS.2012.2211035 | DOI Listing |
Sensors (Basel)
December 2024
Department of Information Management, Tunghai University, Taichung 407224, Taiwan.
Today, huge amounts of time series data are sensed continuously by AIoT devices, transmitted to edge nodes, and to data centers. It costs a lot of energy to transmit these data, store them, and process them. Data compression technologies are commonly used to reduce the data size and thus save energy.
View Article and Find Full Text PDFProteins
November 2024
School of Information and Control Engineering, Qingdao University of Technology, Qingdao, China.
Exploring protein-protein interaction sites (PPIS) is of significance to elucidating the intrinsic mechanisms of diverse biological processes. On this basis, recent studies have applied deep learning-based technologies to overcome the high cost of wet experiments for PPIS determination. However, the existing methods still suffer from two limitations that remain to be solved.
View Article and Find Full Text PDFNucl Med Commun
January 2025
Department of Nuclear Medicine, Saglik Bilimleri University Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.
Purpose: The present study aimed to predict the prognostic role of quantitative 18 F-fluorodeoxyglucose PET/computed tomography parameters such as maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained from primary tumor, lymph node metastases, and liver metastasis (LM) in patients with colorectal LM (CLM).
Material And Method: The research was designed as a retrospective study and 66 patients with CLM were enrolled between January 2017 and December 2018. Primary tumor SUV max (PSUV max ), liver SUV max (LSUV max ), and lymph node SUV max (LnSUV max ) values obtained from the primary tumor, liver, and lymph nodes were recorded.
World J Gastroenterol
October 2023
Department of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
Background: Comprehensive genomic analysis has shown that small bowel adenocarcinoma (SBA) has different genomic profiles from gastric and colorectal cancers. Hence, it is essential to establish chemotherapeutic regimens based on SBA characteristics. The expression of programmed cell death-ligand 1 (PD-L1) and programmed cell death-ligand 2 (PD-L2) in SBA is not fully understood.
View Article and Find Full Text PDFCancer Med
November 2023
Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, P. R. China.
Background: Lateral lymph node metastasis (LLNM) is common in patients with papillary thyroid cancer (PTC), usually occurring after central lymph node metastasis (CLNM). However, some patients experience LLNM without first developing CLNM. This study aimed to identify the risk factors for developing LLNM without CLNM.
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