In this paper, a new approach based on least squares support vector machines (LS-SVMs) is proposed for solving linear and nonlinear ordinary differential equations (ODEs). The approximate solution is presented in closed form by means of LS-SVMs, whose parameters are adjusted to minimize an appropriate error function. For the linear and nonlinear cases, these parameters are obtained by solving a system of linear and nonlinear equations, respectively. The method is well suited to solving mildly stiff, nonstiff, and singular ODEs with initial and boundary conditions. Numerical results demonstrate the efficiency of the proposed method over existing methods.
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http://dx.doi.org/10.1109/TNNLS.2012.2202126 | DOI Listing |
Bioinformatics
January 2025
Department of Pathology and Department of Immunobiology, Yale School of Medicine.
Summary: With the increased reliance on multi-omics data for bulk and single cell analyses, the availability of robust approaches to perform unsupervised learning for clustering, visualization, and feature selection is imperative. We introduce nipalsMCIA, an implementation of multiple co-inertia analysis (MCIA) for joint dimensionality reduction that solves the objective function using an extension to Non-linear Iterative Partial Least Squares (NIPALS). We applied nipalsMCIA to both bulk and single cell datasets and observed significant speed-up over other implementations for data with a large sample size and/or feature dimension.
View Article and Find Full Text PDFLipids Health Dis
January 2025
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Background: Age-related macular degeneration (AMD) decrease vision and presents considerable challenges for both public health and clinical management strategies. Obesity is usually implicated with increased AMD, and body mass index (BMI) does not reflect body fat distribution. An array of studies has indicated a robust relationship between body fat distribution and obesity.
View Article and Find Full Text PDFBMC Med Res Methodol
January 2025
Department of Computer Science and Engineering, School of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran.
Time-to-event data are very common in medical applications. Regression models have been developed on such data especially in the field of survival analysis. Kernels are used to handle even more complicated and enormous quantities of medical data by injecting non-linearity into linear models.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Background: The health benefits of physical activity, including walking, are well-established, but the relationship between daily step count and mortality in hypertensive populations remains underexplored. This study investigates the association between daily step count and both all-cause and cardiovascular mortality in hypertensive American adults.
Methods: We used data from the National Health and Nutrition Examination Survey 2005-2006, including 1,629 hypertensive participants with accelerometer-measured step counts.
Sci Rep
January 2025
The Orthopaedic Medical Center, Second Hospital of Jilin University, Changchun, Jilin Province, China.
This study aims to investigate the association between serum copper (Cu), selenium (Se), zinc (Zn), Se/Cu and Zn/Cu ratios and the risk of sarcopenia. In this study, which involved 2766 adults aged ≥ 20 years enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016, multivariable logistic regression, restricted cubic spline (RCS) models and mediation analyses were used. After full adjustment, multivariable logistic regression revealed that higher serum copper levels were correlated with an increased risk of sarcopenia.
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