Imprints of haematoxilin-eosin and Giemsa-stained, 33 surgically removed different intracranial tumors were examined. In case of sufficient number of cells and adequate clinical data, the cytological examination was suitable to quick intraoperative diagnosis in majority of cases. Its demonstration on GFAP smear facilitates the diagnosing of gliomas.
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Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against liver self-antigens, but how these autoreactive T cells relate to liver tissue pathology remains unclear. Here we perform single-cell transcriptomic and T cell receptor analyses of circulating, self-antigen-specific CD4 T cells from patients with AILD and identify a subset of liver-autoreactive CD4 T cells with a distinct B-helper transcriptional profile characterized by PD-1, TIGIT and HLA-DR expression. These cells share clonal relationships with expanded intrahepatic T cells and exhibit transcriptional signatures overlapping with tissue-resident T cells in chronically inflamed environments.
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School of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
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