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A Rare Case of Fatal Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient with Rheumatoid Arthritis.
Curr Drug Saf
January 2025
Topiwala National Medical College & BYL Nair Charitable Hospital, Clinical Pharmacology, India.
Introduction: This case study presents a rare and fatal instance of Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome in a 51-year-old male patient diagnosed with Rheumatoid Arthritis (RA).
Case Presentation: The patient was initially treated with sulfasalazine, leflunomide, and hydroxychloroquine, following which he developed a rash, fever, and loose stools. Drug allergy was suspected, and the antirheumatic medications were withdrawn, following which, the patient improved.
Two Rare Cases of Feline Toxic Epidermal Necrolysis: A Novel Therapeutic Approach With Medical-Grade Honey.
Case Rep Vet Med
October 2024
R&D Department, Triticum Exploitatie BV, Sleperweg 44 6222 NK, Maastricht, Netherlands.
Toxic epidermal necrolysis (TEN) is an acute and life-threatening dermatological condition that is drug-induced and characterized by extensive epidermal detachment. These lesions should be protected from infection using a product that has a low risk of reactivity. Medical-grade honey (MGH) exerts antimicrobial and wound-healing effects while posing a low risk of exacerbating TEN.
View Article and Find Full Text PDFDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with Multiple Drugs (Leflunomide and Cefuroxime): A Case Report.
Curr Drug Saf
September 2024
Department of Pharmacognosy, Goa College of Pharmacy, Government of Goa, Panaji, Goa.
Article Synopsis
- Adverse Drug Reactions (ADRs) can occur even when medications are taken correctly, with DRESS syndrome being a severe type that affects multiple organ systems and requires quick diagnosis and withdrawal of the offending drug to improve outcomes.
- A case study of a 42-year-old woman highlights DRESS syndrome development after taking leflunomide, leading to serious symptoms including fever, skin rash, and liver injury, confirmed as a "definite" ADR.
- The study emphasizes that both leflunomide and cefuroxime can trigger DRESS syndrome, underscoring the need for careful monitoring of these medications and proper reporting of adverse reactions.
Minimally Invasive Chevron Akin Osteotomy for Hallux Valgus Correction.
JBJS Essent Surg Tech
January 2024
Department of Orthopedic Surgery, University of Texas Medical Branch, Galveston, Texas.
Background: The minimally invasive chevron Akin osteotomy technique is indicated for the treatment of symptomatic mild to moderate hallux valgus deformities. The aim of the procedure is to restore alignment of the first ray while minimizing soft-tissue disruption.
Description: Prior to the procedure, radiographs are utilized to characterize the patient's hallux valgus deformity by determining the hallux valgus angle and intermetatarsal angle.
Antituberculosis-Drugs Induced DRESS: A Multidrug Hypersensitivity or Drug Hypersensitivity Relapse? A Case Report.
Hosp Pharm
February 2024
Department of Clinical Pharmacology, Fatouma Bourguiba University Hospital, Monastir, Tunisia.
DRESS related to first-line antituberculosis drugs (ATD) is a challenging diagnosis. With a long-lasting combined treatment of 4-concomitantly administrated drugs, identification of the culprit drug remains difficult and may expose patients to treatment interruption and affect their outcome. A 42-year-old female, treated with isoniazid, rifampicin, pyrazinamide and ethambutol for multifocal tuberculosis, developed, 40 days later, hyperthermia, facial edema, cervical lymphadenopathy and generalized exanthema.
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