AI Article Synopsis
- Long-term treatment of essential hypertension patients with autonomic dysfunction using lisinopril and indapamide improved heart rate variability and increased humoral system activity.
- Adding bisoprolol, a selective beta-blocker, to the treatment helped normalize the humoral activity.
- This suggests that a tiered approach to RAAS (Renin-Angiotensin-Aldosterone System) blockade could be more effective for controlling neurohumoral systems in patients with essential hypertension and initial sympathicotonia.
Article Abstract
Long-term treatment of patients with essential hypertension (EH) and autonomic dysfunction (sympathicotonia type) with lisinopril in combination with indapamide augmented activity of humoral systems and improved heart rate variability. Addition of a selective beta-blocker bisoprolol to lisinopril/indapamide combination promoted normalization of humoral activity. This gives reason to apply tiered RAAS blockade in order to ensure more effective control of activity of neurohumoral systems in patients with EH ant initial sympathicotonia.
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