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Application of iPS cell-derived macrophages to cancer therapy. | LitMetric
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Application of iPS cell-derived macrophages to cancer therapy.

Satoru Senju Chihiro Koba Miwa Haruta Yusuke Matsunaga Keiko Matsumura Eriko Haga Yuko Sasaki Tokunori Ikeda Koutaro Takamatsu Yasuharu Nishimura

Oncoimmunology

Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan.

Published: January 2014

We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008454PMC
http://dx.doi.org/10.4161/onci.27927DOI Listing

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