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Assessing online chat-based artificial intelligence models for weight loss recommendation appropriateness and bias in the presence of guideline incongruence.
Int J Obes (Lond)
January 2025
Department of Gastroenterology and Hepatology, University of Illinois College of Medicine, Peoria, IL, USA.
Background And Aim: Managing obesity requires a comprehensive approach that involves therapeutic lifestyle changes, medications, or metabolic surgery. Many patients seek health information from online sources and artificial intelligence models like ChatGPT, Google Gemini, and Microsoft Copilot before consulting health professionals. This study aims to evaluate the appropriateness of the responses of Google Gemini and Microsoft Copilot to questions on pharmacologic and surgical management of obesity and assess for bias in their responses to either the ADA or AACE guidelines.
View Article and Find Full Text PDFStiff Person Syndrome and Brittle Type 1 Diabetes: Report of 2 Cases.
AACE Clin Case Rep
July 2024
Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Background/objective: Stiff person syndrome (SPS) and type 1 diabetes (T1D) are heterogeneous disorders characterized by antibodies (Abs) against glutamic acid decarboxylase (GAD).
Case Report: We describe 2 patients with T1D and autoimmune thyroid disease who presented with muscle rigidity and intermittent spasms that affected gait and with elevated circulating anti-GAD titers. Classic SPS and stiff limb syndrome were diagnosed, respectively.
Non-Islet-Cell Tumor Hypoglycemia Secondary to Malignant Phyllodes Tumor of the Breast.
AACE Clin Case Rep
July 2024
Endocrine Department, Tan Tock Seng Hospital, Singapore.
Background/objective: Non-islet cell tumor hypoglycemia (NICTH) is an uncommon condition, of which only a few cases caused by malignant phyllodes tumor of the breast have been reported. We describe a case of NICTH secondary to malignant phyllodes tumor with good response to glucocorticoid therapy.
Case Report: A 62-year-old woman with a rapidly enlarging left breast mass presented with drowsiness and a capillary blood glucose level of 32.
Case Report: IgG4-Related Disease Presenting With Isolated Hypophysitis.
AACE Clin Case Rep
July 2024
Division of Endocrinology and Metabolism, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Article Synopsis
- IgG4-related disease (IgG4-RD) is an immune condition that can affect multiple organs, including the pituitary gland, and can present as hypophysitis, which may mimic more severe issues like pituitary apoplexy.
- A 49-year-old woman experienced symptoms such as abdominal pain and low cortisol levels, leading to imaging that revealed a pituitary macroadenoma; however, surgery revealed the condition to be IgG4-related hypophysitis, not a tumor.
- Diagnosis and treatment of IgG4-RH involve imaging studies, blood tests, and histopathology, with glucocorticoids and hormone replacements being the primary therapies, emphasizing the need for awareness of this condition in
Severe Hyponatremia Triggered by Immune Checkpoint Inhibitor Therapy in a Patient With Mulvihill-Smith Syndrome.
AACE Clin Case Rep
March 2024
Division of Endocrinology, Department of Medicine, Montefiore Medical Center, Bronx, New York.
Background/objective: Immune checkpoint inhibitors (ICI), including Programmed Cell Death 1, Programmed Cell Death Ligand 1, and Cytotoxic T-lymphocyte Associated Antigen 4 inhibitors, upregulate T-cell responses against tumor cells and are becoming a cornerstone in the treatment of various advanced solid and hematological cancers. Mulvihill-Smith Syndrome (MSS) is a rare genetic syndrome that has been associated with metabolic abnormalities and early-onset tumors, including malignancies. We report the first known case of ICI-induced hyponatremia attributable to syndrome of inappropriate antidiuretic hormone ADH release (SIADH) in a patient with MSS.
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