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Associations of essential trace metals with telomere length in general population: a cross-sectional study.
Sci Rep
March 2025
Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations.
View Article and Find Full Text PDFShort Telomere Syndrome in a patient with Primary Sjögren's Syndrome related Interstitial Lung Disease.
Am J Med Sci
March 2025
Lung Transplant and ECMO Program, Department of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, Florida, USA. Electronic address:
Interstitial lung disease (ILD) is a known complication of Primary Sjögren's syndrome (SS). We report the case of a 56-year-old man with a history of SS (SS-A positive) who was admitted with ILD exacerbation, causing respiratory failure requiring extracorporeal life support. Given the family history of rapidly progressive ILD and mixed connective tissue disease in his brother, the patient was tested for short telomere syndrome (STS) during hospitalization and found to have leukocyte telomere length (LTL) around the first percentile, suggesting the diagnosis of STS.
View Article and Find Full Text PDFImpact of Ethnicity on the Relationship Between Telomere Length and Metabolic Markers - a Multi-Ethnic Study from Kuwait.
J Clin Endocrinol Metab
March 2025
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
Objective: Telomere plays a critical role in maintaining genomic stability, and its length serves as a marker of cellular aging. Emerging evidence projects telomere length as a clinical risk factor for metabolic diseases. Our current study examines the associations between telomere length and demographic factors including metabolic health in a multi-ethnic cohort to provide insight into the impact of ethnicity on the potential use of telomere length as a biomarker for assessing diabetes risk.
View Article and Find Full Text PDFImmigrant status and citizenship relationships with epigenetic aging in a representative sample of United States adults.
Epigenomics
March 2025
Department of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Background: Immigrant status and citizenship influence health and well-being, yet their associations with DNA methylation (DNAm)-based biomarkers of aging - key predictors of healthspan and lifespan, also known as epigenetic aging - remain underexplored.
Methods: Using a representative sample of 2,336 United States (U.S.
Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study.
Geroscience
March 2025
Key Laboratory of Trace Elements and Endemic Diseases, School of Public Health, National Health and Family Planning Commissionhealth Science Centerjiaotong University, Xi'an, 710061, China.
Aging is a driving factor of various non-communicable diseases. Air pollution and greenspace also affect human health to varying degrees. However, the relationship between air pollution, green space and aging has not been clearly studied.
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