Objective: To compare the efficacy and safety of hand-assisted laparoscopic colectomy (HALC) and open colectomy (OC) for patients with slow transit constipation (STC).
Methods: Data of patients with STC who underwent total colectomy from January 2008 to December 2012 were retrospectively reviewed after clinical evaluation and an exclusion of secondary causes. These patients were further divided into the HALC and OC groups. Patients' outcomes, including intraoperative and postoperative data on their recovery and complications were compared between the two groups.
Results: A total of 68 patients with STC were finally enrolled in the study, including 32 in the HALC group and 36 in the OC group. The baseline characteristics did not significantly differ between the two groups. Compared with the OC group, patients in the HALC group had a shorter length of incision, a longer operative time and less blood loss volume. There was no conversion to OC for patients undergoing HALC and no intraoperative complications in both groups. Furthermore, after operation, patients in HALC group experienced less pain (3.4 ± 0.7 vs 4.8 ± 1.0), earlier first passage of flatus (58.3 ± 6.3 h vs 73.4 ± 13.0 h), shorter length of postoperative hospital stay (8.8 ± 1.2 days vs 11.3 ± 1.7 days) but higher medical cost (RMB 33 979 ± 3 135 vs RMB 29 828 ± 3 216). The overall postoperative complications and the satisfaction in defecation were comparable in the two groups.
Conclusion: HALC is a safe, minimally invasive and effective surgical alternative for treating STC, which is comparable to OC.
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http://dx.doi.org/10.1111/1751-2980.12156 | DOI Listing |
Food Funct
November 2024
Faculty of Biotechnologies (BioTech), ITMO University 191002, 9 Lomonosova Street, Saint Petersburg, Russia.
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated. The degree of hydrolysis was influenced by the enzyme type, where an order of H-Pan (37.5%) > H-Alc (33.
View Article and Find Full Text PDFInt J Mol Sci
July 2023
Chemistry Department, Moscow M. V. Lomonosov State University, 119991 Moscow, Russia.
Statistical analysis of halogen...
View Article and Find Full Text PDFSubst Abuse
November 2022
Peter Boris Centre for Addictions Research, McMaster University & St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Background: Individuals with substance use disorders (SUDs) have highly heterogeneous presentations and identifying more homogeneous subgroups may foster more personalized treatment. This study used SUD and other psychiatric indicators to characterize latent subgroups of patients in a large inpatient addiction treatment program. The resulting subgroups were then analyzed with respect to differences on clinically informative motivational mechanisms.
View Article and Find Full Text PDFDrug Metab Lett
January 2022
Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad, Uttar Pradesh, India.
Aims: The study was aimed at exploring the role of Acetyl L-Carnitine supplementation attenuating dementia and degradation of cognitive abilities in Hyperhomocysteinemia induced AD manifestations in the mouse model.
Background: Alzheimer's disease (AD) is a neurological disorder that is marked by dementia, and degradation of cognitive abilities. There is great popularity gained by natural supplements as the treatment for AD, due to the higher toxicities of synthetic drugs.
Surg Laparosc Endosc Percutan Tech
December 2019
Department of General Surgery, China-Japan Friendship Hospital, Beijing, P.R. China.
Purpose: The current study aims to explore the effect of myocardial infarction associated transcript (MIAT) level on the long-term prognosis of hand-assisted laparoscopic colectomy (HALC) or laparoscopic-assisted colectomy (LAC) for colorectal cancer (CC).
Materials And Methods: A total of 320 CC patients were included. Patients were randomized into HALC and LAC group.
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