Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells.

Sci Rep

1] Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 [2] PRESTO Investigator, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.

Published: May 2014

AI Article Synopsis

  • The study shows that BAR family proteins can alter the shape of cell membranes in real-time within living cells.
  • When activated, these BAR molecules cause noticeable changes in how organelles curve and orient their membranes.
  • This quick-response method could help researchers explore the connections between the structure and function of organelles inside cells.

Article Abstract

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894391PMC
http://dx.doi.org/10.1038/srep04693DOI Listing

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