AI Article Synopsis
- Preterm infants exhibit a distinct "aged" phenotype, which includes poorer metabolic health compared to term-born infants, necessitating ongoing health monitoring to identify potential long-term issues.
- The study explores the hypothesis that preterm infants experience changes in telomere attrition rates, which could serve as a prognostic biomarker for health outcomes.
- The article reviews existing research on telomere length analysis in preterm infants and evaluates the methods available for measuring telomere length.
Article Abstract
Preterm infants develop an 'aged' phenotype in comparison with term-born infants, one component of which is adverse metabolic health and, therefore, long-term health follow-up is warranted to identify morbidity. In light of this, the identification and use of biomarkers to aid with prognosis would be a welcome development. Telomeres are repeat sequences at the ends of each chromosome arm known to shorten as a consequence of cellular aging, and in relation to several disease conditions. The hypothesis that expreterm infants manifest alterations in telomere attrition rate is, therefore, one of interest. Analysis of telomere length maybe a plausible technique to predict prognosis in relation to preterm birth, and early life environmental and nutritional exposures. In this article, we review the literature on telomere length analysis in the preterm infant population and examine the tools available to measure telomere length.
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| http://dx.doi.org/10.2217/bmm.14.13 | DOI Listing |
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