Objective: To investigate the clinical characteristics of and risk factors for candidemia combined with bacterial bloodstream infection(BSI) by retrospective analysis of cases.
Method: The clinical data of cases diagnosed as candidemia combined with BSI confirmed by blood culture were compared with those of cases with mono-candidemia in Beiing Tongren Hospital from January 2009 to December 2011. A logistic regression analysis was performed to investigate the independent risk factors.
Results: Forty-two cases diagnosed as candidemia were analyzed including 14 cases of candidemia combined with BSI and 28 cases of mono-candidemia. Ten strains of gram-positive cocci and 4 strains of gram-negative bacilli were isolated from candidemia combined with BSI group.Six strains of C.albicans, 4 strains of C.glabrata, 3 strains of C.tropicalis and 1 strain of C.krosei were isolated. There was no C.parapsilosis isolated from candidemia combined with BSI group but 9 strains in the mono-candidemia group. The septic shock rate of the candidemia combined with BSI group was higher than that of the mono-candidemia group (12/14 vs 7/28, P = 0.000). The mortality rate of the candidemia combined with BSI group was higher than that of the mono-candidemia group (10/14 vs 15/28), but the difference did not reach statistical significance (P = 0.266).Four factors were found statistically different by univariate analysis, including hospitalization more than 4 weeks (P = 0.001), bacteremia before candidemia(P = 0.005), hematological tumor (P = 0.01) and abdominal infection (P = 0.001). Multivariate analysis showed that hospitalization more than 4 weeks was the independent risk factor.
Conclusion: Gram-positive cocci were the predominant species and septic shock was more common in candidemia combined with BSI. Hospitalization more than 4 weeks was the independent risk factor for candidemia combined with BSI.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient.
Int J Infect Dis
February 2025
Institut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, France; UR 3738-CICLY-Equipe Inflammation et Immunité de L'épithélium Respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:
This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area.
View Article and Find Full Text PDFThe early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans.
Sci Rep
November 2024
Science for Life Laboratory (SciLifeLab), Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.
Candida albicans is a leading cause of fungal infections in immunocompromised patients. Management of candidemia relies on a few antifungal agents, with fluconazole being first line therapy. The emergence of fluconazole-resistant strains highlights the pressing need to improve our molecular understanding of the drug response mechanisms.
View Article and Find Full Text PDFRisk factors associated with short-term mortality in patients with candidemia and the predictive value of serum cytokine level.
Cytokine
January 2025
Department of Infectious Diseases, Tongling People's Hospital, Tongling 244000, China.
Background: Some pro-inflammatory and anti-inflammatory cytokines were significantly elevated in patients with candidemia patients, but no studies have included these cytokines in the analysis of risk factors for mortality of candidemia. This study aims to analyze the risk factors of short-term mortality of candidemia and the predictive value of serum cytokines.
Methods: We retrospectively analyzed and compared the clinical features, risk factors and cytokine interleukin (IL)-6, interferon-γ (IFN-γ), IL-10 and IL-17 between survival group and death group in 53 patients with candidemia.
Rapid identification of the predominant azole-resistant genotype in Candida tropicalis.
FEMS Yeast Res
January 2024
Taiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Article Synopsis
- * The study examined two specific genes, XYR1 and SNQ2, in a collection of 281 C. tropicalis samples from Taiwan and other global locations to identify markers for these resistant genotypes.
- * The researchers found significant associations between particular codon sequences and clade 4, leading to the development of a TaqMan SNP genotyping assay that could accurately detect azole-resistant strains, improving infection management strategies.
The combined use of the Charlson Comorbidity Index and National Early Warning Score 2 helps predict the prognosis of candidemia.
J Infect Chemother
January 2025
Division of Infection Control, Kagoshima City Hospital, Kagoshima, Japan.
Background: The National Early Warning Score 2 (NEWS2) standardizes assessment and response to acute illnesses using vital signs. Whether NEWS2 is useful in predicting the prognosis of candidemia remains to be determined.
Methods: Our study, conducted as a rigorous and retrospective analysis, examined patients with candidemia who were hospitalized between January 2014 and December 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!