In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007044 | PMC |
| http://dx.doi.org/10.5487/TR.2014.30.1.049 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Access in all areas? A roundup of developments in market access and health technology assessment: part 6.
J Comp Eff Res
January 2025
Centre for Pharmaceutical Medicine Research, King's College London, SE1 9NH, UK.
In this update, we discuss an article covering the implementation challenges of the upcoming European Union Health Technology Assessment regulation, particularly focusing on the complexity of population, intervention, comparator and outcomes requirements across member states; a user guide to applying generalized cost-effectiveness analysis for broader value assessment and finally highlight an ongoing debate surrounding National Institute for Health and Care Excellence's severity modifier implementation.
View Article and Find Full Text PDFEvaluation of the effectiveness of medroxyprogesterone on blood gases and short-term hospital outcomes in patients with chronic obstructive pulmonary disease treating with noninvasive ventilation: A randomized clinical trial.
J Res Med Sci
November 2024
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: In the present study, we aimed to evaluate the effects of medroxyprogesterone on hospital short clinical outcomes and ABG parameters in patients with chronic obstructive pulmonary disease (COPD) exacerbation under treatments with noninvasive ventilation (NIV) treated with progesterone 15 mg in comparison with placebo.
Materials And Methods: This is a double-blinded clinical trial that was performed in 2020-2021 in Isfahan, Iran, on 60 patients with COPD exacerbation that require NIV. All patients received short-acting beta-agonists, short-acting anticholinergics, systemic corticosteroids, and NIV.
Ossicular Chain Reconstruction With Glass Ionomer Cement Following Removal of Active Middle Ear Implant.
OTO Open
January 2025
Shohet Ear Associates Medical Group Inc. Orange County California USA.
The use of bone cement in ossicular chain reconstruction (OCR) represents an area of recent interest. This multi-institutional retrospective study assesses the efficacy of glass ionomer cement (GIC) in OCR following the explantation of a fully implantable active middle ear implant. A postoperative 4-frequency mean air-bone gap (ABG) was obtained for 15 subjects by averaging 0.
View Article and Find Full Text PDFAnomalous Pulmonary Vein Drainage Into the Innominate Vein Diagnosed After Central Line Placement: A Case Report Along With a Review of Rare Congenital Anatomy Partial Anomalous Pulmonary Venous Return.
J Med Cases
January 2025
Department of Surgery, Arrowhead Regional Medical Center, Colton, CA, USA.
Anomalous pulmonary vein drainage is a rare but clinically relevant variant of the cardiovascular anatomy. We present a case report of a 22-year-old male who was incidentally found to have anomalous pulmonary vein drainage into the innominate vein. The patient had a known history of seizures and was brought to the emergency department following a simple tonic-clonic seizure.
View Article and Find Full Text PDFInfluence of the wet-ear state on the outcomes of tympanic membrane repair under ear endoscopy: a prospective case-control study.
BMC Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Zhangqiu People's Hospital, No.1920 Mingshui Huiquan Road, Zhangqiu Distict, Jinan, 250200, People's Republic of China.
Background: To prospectively determine whether tympanoplasty for tympanic membrane perforation (TMP) in wet ears impacts recovery.
Methods: We prospectively enrolled 32 TMP patients (2021-2023) and divided them into the wet-ear (14 patients) and dry-ear groups (18 patients), according to the presence of middle-ear secretions/edema. All patients underwent high-resolution thin-slice computed tomography, ear endoscopy, and pure tone audiometry.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!