AI Article Synopsis
- A brain lesion was found in a 6-year-old female cynomolgus macaque during a toxicology study, but no visible gross lesions were seen during the necropsy.
- The microscopic examination revealed larvae consistent with Baylisascaris spp., surrounded by inflammatory cells and connective tissue.
- A diagnosis of neural Baylisascaris spp. larva migrans was established based on the observed histological characteristics of the lesion.
Article Abstract
An incidental, asymptomatic, focal inflammatory lesion was detected in brain cerebrum of an approximately 6-year-old, female cynomolgus macaque from a chronic toxicology study. No gross lesions were noted at necropsy. Microscopically, the lesion contained a cross-section of larvae approximately 70-80 μm in diameter, a centrally located intestine flanked on either side by large triangular excretory columns, and prominent single lateral cuticular alae. Mixed inflammatory cells of eosinophils, macrophages, and lymphocytes admixed with abundant connective tissue stroma and necrosis surrounded the larvae. Histochemical stains for trichrome revealed significant amount of fibrous connective tissue. The morphology of the larvae was compatible with Baylisascaris spp. Based on the microscopic and histochemical examination, a diagnosis of neural Baylisascaris spp. larva migrans was made.
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| http://dx.doi.org/10.1016/j.etp.2014.03.004 | DOI Listing |
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