AI Article Synopsis
- Electrical impedance spectroscopy was used on post-mortem mouse brains with a flexible probe and micrometric electrode array to measure the intrinsic resistivity of brain tissues at a high resolution.
- The study successfully differentiated resistivity values in various brain structures, such as the cortex, ventricles, and thalamus, and found that these values correlate with the density of cell bodies in different cortical layers.
- Impedance measurements on cauterized brain models demonstrated the technique's ability to assess the extent and severity of tissue damage caused by cauterization.
Article Abstract
Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining intrinsic resistivity values of brain tissues and structures with submillimetric resolution. Reproducible resistivity measurements are reported, which allows the resistivity in the cortex, ventricle, fiber tracts, thalamus and basal ganglia to be differentiated. Measurements of brain slices revealed resistivity profiles correlated with the local density of cell bodies hence allowing to discriminate between the different cortical layers. Finally, impedance measurements were performed on a model of cauterized mouse brain evidencing the possibility to measure the spatial extent and the degree of the tissue denaturation due to the cauterization.
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| http://dx.doi.org/10.1016/j.bios.2014.03.044 | DOI Listing |
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