AI Article Synopsis
- - Interleukin-10 (IL-10) is an important anti-inflammatory cytokine that plays a key role in immune responses, especially in inflammatory bowel diseases.
- - Researchers studied the role of IL-10 produced by intestinal macrophages and the effects of mutations in IL-10 and its receptor specifically in a type of gut macrophage.
- - They found that while IL-10 production by macrophages is not essential for gut health, the absence of IL-10 receptor leads to severe colitis, highlighting the importance of IL-10 in regulating gut inflammation.
Article Abstract
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome-wide association studies and experimental animal models point at a central role of the IL-10 axis in inflammatory bowel diseases. Here we investigated the importance of intestinal macrophage production of IL-10 and their IL-10 exposure, as well as the existence of an IL-10-based autocrine regulatory loop in the gut. Specifically, we generated mice harboring IL-10 or IL-10 receptor (IL-10Rα) mutations in intestinal lamina propria-resident chemokine receptor CX3CR1-expressing macrophages. We found macrophage-derived IL-10 dispensable for gut homeostasis and maintenance of colonic T regulatory cells. In contrast, loss of IL-10 receptor expression impaired the critical conditioning of these monocyte-derived macrophages and resulted in spontaneous development of severe colitis. Collectively, our results highlight IL-10 as a critical homeostatic macrophage-conditioning agent in the colon and define intestinal CX3CR1(hi) macrophages as a decisive factor that determines gut health or inflammation.
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| http://dx.doi.org/10.1016/j.immuni.2014.03.012 | DOI Listing |
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