AI Article Synopsis
- Chronic cerebral hypoperfusion and aging are linked to vascular dementia, which leads to cognitive decline and memory issues; identifying early biomarkers is crucial for creating neuroprotective treatments.
- The study utilized a three-vessel occlusion (3-VO) model in middle-aged rats to analyze the impact of global cerebral hypoperfusion using techniques like magnetic resonance spectroscopy and histology.
- Results indicated significant changes in brain structure and metabolism, including cell death in the hippocampus and mild behavioral changes, highlighting the importance of understanding vascular-related cognitive decline for potential early intervention strategies.
Article Abstract
Chronic cerebral hypoperfusion and aging can be related to vascular dementia manifested by the decline in cognitive abilities and memory impairment. The identification of specific biomarkers of vascular disorder in early stages is important for the development of neuroprotective agents. In the present study, a three-vessel occlusion (3-VO) rat model of vascular dementia in the middle-aged rat brain was used to investigate the effect of global cerebral hypoperfusion. A multimodal study was performed using magnetic resonance spectroscopy, MR-microimaging, histology and behavioral tests. Our measurements showed a signal alteration in T2-weighted MR images, the elevation of T2 relaxation times and histologically proven neural cell death in the hippocampal area, as well as mild changes in concentration of proton and phosphorus metabolites. These changes were accompanied by mild behavioral alterations in the open field and slightly decreased habituation. The analysis of the effects of vascular pathology on cognitive functions and neurodegeneration can contribute to the development of new treatment strategies for early stages of neurodegeneration.
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| http://dx.doi.org/10.1016/j.brainres.2014.04.032 | DOI Listing |
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