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Induced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal. | LitMetric

Induced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal.

Cell Stem Cell

Immunology Section, Institution for Experimental Medical Science, Lund University, Sölvegatan 17, BMC D14, 221 84, Lund, Sweden. Electronic address:

Published: May 2014

Obtaining sufficient numbers of immunologically matched hematopoietic stem cells (HSCs) poses a major clinical hurdle in bone marrow transplantation therapies. In a recent study in Cell, Riddell et al. (2014) generate induced HSCs from differentiated blood cells, which may serve as a potential solution to this clinical challenge.

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http://dx.doi.org/10.1016/j.stem.2014.04.008DOI Listing

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