Objective: Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults.
Design: Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT).
Participants: 426 women from WHI older than age 50 years, and 509 men older than age 55 years (age 50 years for African American men) from SELECT.
Measurements: 65 candidate gene SNPs that were judged by consensus, based on a literature review, as being related to predisposition to optimism and resilience, and 31 ancestry informative marker SNPs, genotyped from blood-based DNA samples and self-report scales for trait optimism, resilience, and depressive symptoms.
Results: Using a Bonferroni threshold for significant association (p = 0.00089), there were no significant associations for individual SNPs with optimism or resilience in single-locus analyses. Exploratory multi-locus polygenic analyses with p <0.05 showed an association of optimism with SNPs in MAOA, IL10, and FGG genes, and an association of resilience with a SNP in MAOA gene.
Conclusions: Correcting for Type I errors, there were no significant associations of optimism and resilience with specific gene SNPs in single-locus analyses. Positive psychological traits are likely to be genetically complex, with many loci having small effects contributing to phenotypic variation. Our exploratory multi-locus polygenic analyses suggest that larger sample sizes and complementary approaches involving methods such as sequence-based association studies, copy number variation analyses, and pathway-based analyses could be useful for better understanding the genetic basis of these positive psychological traits.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163500 | PMC |
| http://dx.doi.org/10.1016/j.jagp.2014.03.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Evidence indicates that many nursing students exhibit signs of burnout and consider leaving nursing during nursing school. However, there is scant literature on the extent of this problem or mitigating factors.
Method: Undergraduate nursing students ( = 129) participated in a correlational study examining patterns of burnout and Psychological Capital (PsyCap), a four-pronged construct that captures hope, efficacy, resilience, and optimism.
Do positive childhood and adult experiences counter the effects of adverse childhood experiences on learned helplessness?
Front Child Adolesc Psychiatry
January 2024
Department of Public Health, Brigham Young University, Provo, UT, United States.
Introduction: Learned helplessness often arises when an individual feels that a challenging situation is inescapable. Childhood trauma can lead to feelings of learned helplessness in youth and adulthood. Resiliency theory suggests that positive experiences in childhood and adulthood may counteract traumatic experiences in childhood and reduce learned helplessness and promote learned optimism, the antithesis of learned helplessness.
View Article and Find Full Text PDFTesting the effectiveness of a new French assisted resilience program among long-term unemployed people: a randomized control trial.
Psychol Health Med
January 2025
Université de Bordeaux, LabPsy, Bordeaux, France.
Long-term unemployment can affect life satisfaction, reduce well-being and increase mental health problems. Promoting psychological resilience to support the ability to cope with life challenges such as unemployment, may be a useful strategy. A specific program named AD-Ré was designed for Long-Term Unemployed (LTU) people in order to improve their mental health by fostering psychological resilience.
View Article and Find Full Text PDFImpact of Emergency Warning Nursing on CRP, PCT, TNF-α and Clinical Indicators in Patients with Acute Stress Disorder under Hierarchical Analysis.
Actas Esp Psiquiatr
January 2025
Clinical Teaching and Research Department, The Southwest Hospital of AMU, 400038 Chongqing, China.
Background: In emergency warning nursing, the pre-alert system significantly influences the biochemical markers and clinical outcomes of patients with Acute Stress Disorder. Therefore, this study applies hierarchical analysis to explore the impact of early warning nursing on crucial indicators such as C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and assess their clinical efficacy.
Methods: The study selected patients with acute stress disorder who were hospitalized in Southwest Hospital of Chongqing from December 2021 to December 2022, and collected data from 250 patients.
[Humanization and professional quality of life in oncohematology and radiotherapy care: A descriptive study in a university hospital].
J Healthc Qual Res
January 2025
Área de Oncohematología y Oncología Radioterápica, Hospital Universitario Doce de Octubre, Madrid, España.
Objective: To evaluate levels of humanization, professional quality of life, resilience, communication skills, and the use of silence among healthcare professionals in these areas.
Methods: Observational, cross-sectional, and descriptive study conducted in a referral hospital. Data were collected from 152 healthcare professionals through questionnaires assessing professional quality of life (ProQOL), resilience (CD-RISC), humanization (HUMAS), communication skills (EHC-PS), and the use of silence (Q-SPS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!