AI Article Synopsis
- This study explores how to create artesunate polylactic acid (PLA) microspheres for use in hepatic arterial embolization and examines their drug release behavior.
- The researchers used a method involving O/W emulsion and solvent evaporation, optimizing factors like PLA concentration and stirring speed through experiments.
- They determined the best preparation conditions, resulting in microspheres with a size of about 101.7 micrometers, a drug loading capacity of 30.8%, and an entrapment rate of 53.6%, indicating a reliable and effective process for further research.
Article Abstract
This study aims to investigate the preparation process and in vitro release behavior of artesunate polylactic acid microspheres, in order to prepare an artesunate polylactic acid (PLA) administration method suitable for hepatic arterial embolization. With PLA as the material and polyvinyl alcohol (PVA) as the emulsifier, O/W emulsion/solvent evaporation method was adopted to prepare artesunate polylactic acid microspheres, and optimize the preparation process. With drug loading capacity, encapsulation efficiency and particle size as indexes, a single factor analysis was made on PLA concentration, PVA concentration, drug loading ratio and stirring velocity. Through an orthogonal experiment, the optimal processing conditions were determined as follows: PLA concentration was 9. 0% , PVA concentration was 0. 9% , drug loading ratio was 1:2 and stirring velocity was 1 000 r x min(-1). According to the verification of the optimal process, microsphere size, drug loading and entrapment rate of artesunate polylactic acid microspheres were (101.7 +/- 0.37) microm, (30.8 +/- 0.84)%, (53.6 +/- 0.62)%, respectively. The results showed that the optimal process was so reasonable and stable that it could lay foundation for further studies.
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