Lp(a) has been well known as an independent risk factor for coronary artery disease (CAD). The LPA gene, as it encodes apo(a) of the Lp(a) lipoprotein particle, was associated with increased risk of CAD. The purpose of this study was to analyze the relationship between the polymorphisms of LPA gene and CAD in Chinese Han population. Five SNPs (rs1367211, rs3127596, rs6415085, rs9347438, and rs9364559) in the LPA gene were genotyped using Sequenom MassARRAY time-of-flight mass spectrometer (TOF) in 560 CAD patients as case group and 531 non-CAD subjects as control group. The numbers of these two groups were from Chinese Han ancestry. The results showed that allele (P = 0.046) and genotype (P = 0.026) of rs9364559 in the LPA gene was associated with CAD. The frequency of rs9364559 minor allele (G) in case group was obviously higher than that in control group. Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population. This study explored rs9364559 in the LPA gene may be associated with the pathogenesis of CAD; and the risk of CAD might be higher in the population carrying 4 haplotypes of different blocks in the LPA gene.
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| http://dx.doi.org/10.1155/2014/370670 | DOI Listing |
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Article Synopsis
- This study explores the relationship between pretreatment serum lipoprotein(a) [Lp(a)] levels and EGFR gene mutations in patients with advanced lung adenocarcinoma undergoing treatment with EGFR-TKIs.
- The research evaluated 338 patients and concluded that a higher Lp(a) level (above 20.48 mg/L) is linked to a lower rate of EGFR mutations (48.0% vs 65.5%).
- The findings also indicate that higher Lp(a) levels are associated with longer progression-free survival (16.1 months vs 9.6 months), suggesting it is a significant independent predictor for both EGFR mutations and PFS.
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