AI Article Synopsis
- A young woman with systemic lupus erythematosus (SLE) showed abnormal heart changes, including interventricular septal hypertrophy (thickening of the heart muscle) and increased pressure between the aorta and heart during high-dose prednisone treatment.
- Upon reducing the prednisone dosage, the heart symptoms, including the pressure gradient and mitral regurgitation, significantly improved, showcasing the drug's impact on heart function.
- This case is notable as it is the only documented instance of myocardial hypertrophy potentially linked to prednisone use in an adult.
Article Abstract
We present a series of echocardiography images to demonstrate the myocardial response to a high dose of prednisone. A young woman with systemic lupus erythematosus (SLE) associated with interventricular septal hypertrophy exhibited a high pressure gradient between the ascending aorta and left ventricular outflow tract as well as significant systolic anterior motion (SAM) and mitral regurgitation (MR) during high-dose prednisone treatment. However, the pressure gradient decreased dramatically and the MR disappeared rapidly when the dose of prednisone was reduced. To the best of our knowledge, this is the only adult case of myocardial hypertrophy that is assumed to be related to prednisone use.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024544 | PMC |
| http://dx.doi.org/10.1136/bcr-2013-203046 | DOI Listing |
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