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Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila.
Kidney Int
June 2022
Renal Division, Department of Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. Electronic address:
Risk variants of the apolipoprotein-L1 (APOL1) gene are associated with severe kidney disease, putting homozygous carriers at risk. Since APOL1 lacks orthologs in all major model organisms, a wide range of mechanisms frequently in conflict have been described for APOL1-associated nephropathies. The genetic toolkit in Drosophila allows unique in vivo insights into disrupted cellular homeostasis.
View Article and Find Full Text PDFDecellularized kidney in the presence of chondroitin sulfate as a natural 3D scaffold for stem cells.
Iran J Basic Med Sci
August 2015
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Objectives: Use of biological scaffolds and automating the cells directing process with materials such as growth factors and glycosaminoglycans (GAGs) in a certain path may have beneficial effects in tissue engineering and regenerative medicine in future. In this research, chondroitin sulfate sodium was used for impregnation of the scaffolds. It is a critical component in extracellular matrix and plays an important role in signaling pathway; however, little is known about its role within mammalian development and cell linage specification.
View Article and Find Full Text PDFThe bioactivity of plasma factors in focal segmental glomerulosclerosis.
Nephron Exp Nephrol
September 2006
Academic and Children's Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK.
Focal segmental glomerulosclerosis (FSGS) is a devastating form of nephrotic syndrome, often leading to end-stage renal failure after the failure of a succession of highly toxic therapies. It has long been thought to be caused by a circulating factor(s) that may be produced by cells of the immune system. Much research has focused on identifying such factor(s), including the development of a promising in vitro assay, which estimates glomerular permeability based on the swelling of isolated glomeruli in response to patients' plasma.
View Article and Find Full Text PDFUpdate in podocyte biology: putting one's best foot forward.
Curr Opin Nephrol Hypertens
May 2003
The Johns Hopkins University, Baltimore, Maryland, USA.
Purpose Of Review: The rapidly developing field of podocyte cell biology is reviewed, focusing on papers published in the last 12 months.
Recent Findings: Four areas of particular progress can be discerned. First, podocytes proliferate during early metanephric development, are quiescent after the capillary loop stage, and re-enter the cell cycle only in the disease group termed collapsing glomerulopathy.
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