Histological diagnosis of thyroid disease using ultrasound-guided core biopsies.

Eur Thyroid J

Department of Radiology, Basurto University Hospital, University of the Basque Country, Bilbao, Spain.

Published: March 2013

AI Article Synopsis

  • Thyroid core biopsies using ultrasound guidance offer an effective alternative to traditional fine-needle aspiration, demonstrating greater sensitivity and specificity while being low-cost and reliable.
  • The study reviewed 1,065 cases over 15 years, confirming that these biopsies are safe and useful for diagnosing thyroid conditions, though they shouldn’t replace fine-needle aspiration entirely.
  • Optimal results from these procedures come from a collaborative effort among medical professionals, emphasizing the importance of understanding what can and cannot be diagnosed using each method.

Article Abstract

Background: Thyroid core biopsies obtained with ultrasound (US)-guided needles are an alternative to conventional fine-needle aspiration and, according to various authors, have greater sensitivity and specificity. The technique is inexpensive, rapid and reliable with a low rate of complications, similar to conventional fine-needle aspiration procedures.

Objectives: This paper critically reviews the methodology for obtaining samples and processing them in the pathology laboratory.

Methods: Accumulated experience with 1,065 cases of US-guided core biopsy of the thyroid gland in a 15-year period.

Results: US-guided core biopsy is a useful, inexpensive and safe method in the histological diagnosis of thyroid gland pathology. Thyroid samples obtained this way are not a substitute for fine-needle aspiration cytology. Indeed, some authors assert that the best results are obtained by combining the two approaches, the methods being complementary.

Conclusions: To take best advantage of the findings from these techniques, pathologists must know which types of diagnoses can be made and the fundamentals of how and, lastly, what cannot be diagnosed and the reasons why. Best results are obtained with a multidisciplinary approach in a hospital committee composed of endocrinologists, surgeons, radiologists and pathologists, who analyse and provide a background on each case.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821498PMC
http://dx.doi.org/10.1159/000343825DOI Listing

Publication Analysis

Top Keywords

fine-needle aspiration
12
histological diagnosis
8
diagnosis thyroid
8
core biopsies
8
conventional fine-needle
8
us-guided core
8
core biopsy
8
thyroid gland
8
thyroid
5
thyroid disease
4

Similar Publications

Background: Thyroid nodules classified cytologically as low-risk indeterminate lesions (TIR3A) on fine-needle aspiration biopsy (FNAB) present a clinical challenge due to their uncertain malignancy risk. This single-center study aimed to evaluate the natural history of TIR3A nodules.

Materials And Methods: FNABs performed between July 2017 and December 2019 were retrospectively retrieved and patients with TIR3A nodules were evaluated at baseline and throughout a follow-up based on ultrasound (US) parameters and clinical data.

View Article and Find Full Text PDF

Objective: An accurate fine-needle aspiration (FNA) diagnosis of adrenal lesions may be challenging. This study was to investigate roles of imaging guidance, rapid on-site evaluation (ROSE) and additional tissue sampling in FNA diagnosis of adrenal lesions.

Methods: Adrenal FNA cases were retrieved from pathology archive.

View Article and Find Full Text PDF

Primary cutaneous anaplastic large cell lymphoma (ALCL) is a very uncommon type of CD30-positive T-cell lymphoma, and it very rarely affects the forehead. We report the case of a 68-year-old male presenting with an ulcerative lesion on the right forehead, initially suspected as a benign condition. Fine needle aspiration suggested a lymphoproliferative disorder, with biopsy and immunohistochemistry confirming primary cutaneous ALCL (CD30-positive, anaplastic lymphoma kinase [ALK]-negative).

View Article and Find Full Text PDF

Introduction: Limited information exists on next-generation sequencing (NGS) success for lung tumors of 30 mm or less. We aimed to compare NGS success rates across biopsy techniques for these tumors, assess DNA sequencing quality, and verify reliability against surgical resection results.

Methods: We used data from the Initiative for Early Lung Cancer Research on Treatment study, including patients with lung tumors measuring 30 mm or less who had surgery and NGS on biopsies since 2016.

View Article and Find Full Text PDF

Evaluation of HER2-Low breast carcinoma in metastatic settings: a cytological approach to proliferation and survival.

J Am Soc Cytopathol

January 2025

Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania; Department of Pathology & Laboratory Medicine, University of Miami Hospital, Miami, Florida.

Introduction: Human epidermal growth factor receptor 2 (HER2)-low breast cancer, defined by HER2 immunohistochemistry scores of 1+ or 2+ without gene amplification, represents a unique subgroup with emerging therapeutic implications. Limited data describe the behavior of HER2-low tumors, particularly in metastatic settings. This study evaluated the frequency of HER2-low expression, Ki-67 proliferation index, and survival outcomes across HER2 subtypes in metastatic breast carcinoma using cytology specimens.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!