AI Article Synopsis
- Researchers developed a nanocomposite called Tween-dopa-LDH by incorporating the anti-Parkinsonian drug levodopa into a Zn/Al-layered double hydroxide (LDH) using a coprecipitation method, followed by coating it with Tween-80.
- X-ray diffraction analysis confirmed the formation of the nanocomposite and thermogravimetric analysis (TGA) revealed a Tween-80 loading of 8.6% on the surface.
- The Tween-dopa-LDH nanocomposite exhibited a slower release of levodopa compared to the uncoated version, and cell viability tests on PC12 cells showed an improvement in cell health due to the Tween-80 coating.
Article Abstract
We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982257 | PMC |
| http://dx.doi.org/10.1155/2014/104246 | DOI Listing |
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