Objective: To retrospectively assess whether cardiopulmonary exercise testing would be well tolerated in individuals with Alzheimer disease (AD) compared with a nondemented peer group.
Design: We retrospectively reviewed 575 cardiopulmonary exercise tests (CPETs) in individuals with and without cognitive impairment caused by AD.
Setting: University medical center.
Participants: Exercise tests (N=575) were reviewed for nondemented individuals (n=340) and those with AD-related cognitive impairment (n=235).
Interventions: Not applicable.
Main Outcome Measures: The main outcome measure for this study was reporting the reason for CPET termination. The hypothesis reported was formulated after data collection.
Results: We found that in cognitively impaired individuals, CPETs were terminated because of fall risk more often, but that overall test termination was infrequent-5.5% versus 2.1% (P=.04) in peers without cognitive impairment. We recorded 6 cardiovascular and 7 fall risk events in those with AD, compared with 7 cardiovascular and 0 fall risk events in those without cognitive impairment.
Conclusions: Our findings support using CPETs to assess peak oxygen consumption in older adults with cognitive impairment caused by AD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149924 | PMC |
| http://dx.doi.org/10.1016/j.apmr.2014.04.007 | DOI Listing |
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