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Case report: Fatal long-term intoxication by 2,4-dinitrophenol and anabolic steroids in a young bodybuilder with muscle dysmorphia.
Front Public Health
December 2024
Department of Legal and Penitentiary Medicine, Rennes University Hospital, Rennes, France.
A case of chronic intoxication by 2,4-dinitrophenol (2,4-DNP) is reported in a 21-year-old bodybuilder, also known as an abuser of anabolic steroids, who died after ingesting 2 grams of this substance after 6 months of repeated consumption. The bodybuilder presented the triad of symptoms - tachycardia, tachypnoea, profuse sweating - from 6 months before his death, and was hospitalised for multiple organ failure 4 months before his death. Medical staff attributed this serious episode to his consumption of 2,4-DNP.
View Article and Find Full Text PDFHypothermia: Pathophysiology and the propensity for infection.
Am J Emerg Med
November 2024
Walter Reed Army Institute of Research, 503 Robert Grant Ave. Silver Spring, MD, 20910, USA. Electronic address:
Hypothermia in combination with infection presents a complex challenge in clinical and battlefield medicine. Multifaceted physiological and immunological consequences of hypothermia drastically change the risk, progression, and treatment of a concomitant infection. Managing hypothermia and infection in extreme cold settings is particularly relevant in an era with increased risk of military operations in Polar climates.
View Article and Find Full Text PDFCombined effect of intermittent hemostasis and a modified external hemorrhage control device in a lethal swine model.
Heliyon
September 2024
Department of Trauma Surgery, Medical Center of Trauma and War Injury, State Key Laboratory of Trauma, Burns and Combined Injuries, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Background: Non-compressible torso hemorrhage (NCTH) presents the ultimate challenge in pre-hospital care. While external hemorrhage control devices (EHCDs) such as the Abdominal Aortic and Junctional Tourniquet (AAJT) and SAM Junctional Tourniquet (SJT) have been invented, the current design and application strategy requires further improvement. Therefore, researchers devised a novel apparatus named Modified EHCD (M-EHCD) and implemented intermittent hemostasis (IH) as a preventive measure against ischemia-reperfusion injury.
View Article and Find Full Text PDFElucidating the molecular properties and anti-mycobacterial activity of cysteine peptidase domain of D29 mycobacteriophage endolysin.
J Virol
October 2024
Microbiology and Molecular Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Emergence of antibiotic resistance in pathogenic () has elevated tuberculosis to a serious global threat, necessitating alternate solutions for its eradication. D29 mycobacteriophage can infect and kill several mycobacterial species including . It encodes an endolysin LysA to hydrolyze host bacteria peptidoglycan for progeny release.
View Article and Find Full Text PDFAssociation of Non-Transfusion-Related Admission Hypocalcaemia With Haemodynamic Instability in Paediatric Major Trauma: A Retrospective Single-Centre Pilot Study.
Cureus
July 2024
Blizard Institute, Queen Mary University London, London, GBR.
Article Synopsis
- - The study focuses on the relationship between ionised hypocalcaemia (iHypoCa) and early hypotension in pediatric trauma patients, emphasizing the potential consequences of iHypoCa on cardiovascular stability and coagulopathy.
- - Conducted as a retrospective analysis from 2016 to 2022, the research included patients under 16 and aimed to identify the incidence of iHypoCa and its correlation with treatment measures and adverse outcomes.
- - Findings indicated that 17.8% of patients showed iHypoCa on admission, with those affected having nearly three times the risk of hypotension, highlighting the need for further research despite the pilot study's limitations.
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