A directed manipulation of the functional groups at C3 and C4 of D-glucose was demonstrated to synthesize naturally occurring (2S,3R)-α-hydroxy-β-aminodecanoic acid (AHDA, 2a) and its enantiomer 2b. The enantiomer of 2a is the N-terminal part of the natural linear pentapeptide microginin, which is used as an antihypertensive agent.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999816 | PMC |
| http://dx.doi.org/10.3762/bjoc.10.59 | DOI Listing |
Publication Analysis
Top Keywords
linear pentapeptide
8
pentapeptide microginin
8
synthesis 2s3r-3-amino-2-hydroxydecanoic
4
2s3r-3-amino-2-hydroxydecanoic acid
4
acid enantiomer
4
enantiomer non-proteinogenic
4
non-proteinogenic amino
4
amino acid
4
acid segment
4
segment linear
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!