The rational-decision approach is superior to the associative-learning approach of Cook et al. at explaining why mirror neurons fire or do not fire - even when the stimulus is the same. The rational-decision approach is superior because it starts with the analysis of the intention of the organism, that is, with the identification of the specific objective or goal that the organism is trying to maximize.
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http://dx.doi.org/10.1017/S0140525X13002355 | DOI Listing |
J Proteomics
December 2024
Department of Biochemistry, Institute of Chemistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil. Electronic address:
This pipeline presents a refined approach for deriving personalized neurobiological insights from iPSC-derived neurospheres. By employing Tandem Mass Tag (TMT) labeling, we optimized sample pooling and multiplexing for robust comparative analysis across experimental conditions, maximizing data yield per sample. Through single-patient-derived neurospheres-composed of neural progenitor cells, early neurons, and radial glia-this study explores proteomic profiling to mirror the cellular complexity of neurodevelopment more accurately than traditional 2D cultures.
View Article and Find Full Text PDFJ Peripher Nerv Syst
December 2024
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.
Background And Aims: Colony-stimulating factor 1 (CSF1) is a growth factor secreted by dorsal root ganglia (DRG) neurons important for DRG macrophages and spinal cord (SC) microglia injury-induced proliferation and activation, specifically released after spared nerve injury (SNI). In this study, we investigated if SNI-induced CSF1 expression and perineuronal rings of macrophages around mouse DRG neurons vary between L3-L5 DRG and with the neuronal type, and if the CSF1 neuronal projections at the SC dorsal horns were associated with an increased microglial number in the corresponding laminae.
Methods: Seven days after surgery, L3-L5 DRG as well as their corresponding segments at the SC level were collected, frozen, and cut.
Basic Clin Neurosci
July 2024
Department of Quantitative Psychology and Economics (QPE), University of Warsaw, Warsaw, Poland.
Humans are inherently complex creatures, and this issue became even more complicated when they decided to construct social relationships. Research into human behavior is an interdisciplinary and multifaceted endeavor studied by various disciplines, such as psychology, economics, sociology, anthropology, and neurosciences. Today, with the cooperation of researchers in different fields, it is possible to link the cellular dynamic of neurons to brain function and human behavior.
View Article and Find Full Text PDFBraz J Psychiatry
November 2024
Laboratory of Panic & Respiration, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Clin Neurophysiol
December 2024
Neurophysiology Lab, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Objectives: Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS).
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